The primary role of CTCF is thought to be in regulating the 3D structure of chromatin. CTCF binds together strands of DNA, thus forming chromatin loops, and anchors DNA to cellular structures like the nuclear lamina. It also defines the boundaries between active and heterochromatic DNA. Since the … See more Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. CTCF is involved in many cellular processes, … See more CCCTC-Binding factor or CTCF was initially discovered as a negative regulator of the chicken c-myc gene. This protein was found to be binding to three regularly spaced repeats of … See more CTCF binds to the consensus sequence CCGCGNGGNGGCAG (in IUPAC notation). This sequence is defined by 11 zinc finger motifs in its structure. CTCF's binding is disrupted by See more • Ohlsson R, Renkawitz R, Lobanenkov V (2001). "CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease". Trends Genet. 17 (9): 520–7. doi:10.1016/S0168-9525(01)02366-6. PMID 11525835. • Klenova EM, Morse … See more The binding of CTCF has been shown to have many effects, which are enumerated below. In each case, it is unknown if CTCF directly evokes the outcome or if it does so indirectly (in particular through its looping role). Transcriptional … See more CTCF binds to itself to form homodimers. CTCF has also been shown to interact with Y box binding protein 1. CTCF also co-localizes with See more • CCCTC-binding+factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • FactorBook CTCF See more WebCharacteristics. strain background: 129. genotype/variation: TDG KO. cell type: mESCs. chip antibody: anti-CTCF (CST, #3418) Growth protocol. Tdg knockout mouse embryonic …
GEM: ChIP-seq and ChIP-exo peak calling and motif …
WebCTCF CTCF defines an AnnotationHub resource representing genomic coordinates of FIMO -predicted CTCF binding sites for human and mouse genomes, including the Telomere … WebJul 25, 2024 · A bedfile folder, providing the genomic coordinates of the first kilobase flanking OCCUPIED CTCF binding sites (CTCF.bed) Fu et al., 2008); A yaml-format makefile (example.yaml), representing the main input file required by epiPALEOMIX and containing path to BAM and BED files as well as indicating which analyses should be … fleetwod motorhome repairs
GEM/README.md at master · gifford-lab/GEM · GitHub
http://www.genome.ucsc.edu/FAQ/FAQformat.html WebThat would count any reads with lengths between 36-149, 150-324, and 325-400 from input.bam whose cut points fell in the specified region around motifs from JASPAR2014_CTCF.bed.gz.The cut point counts would be recorded for each fragment size bin, at nucleotide resolution (with no score aggregation in the extended region around … WebMar 23, 2024 · CTCF sites as insulators in Pcdhα through directional chromatin looping. a Schematic of the three mouse Pcdh clusters. Genomic organizations of the Pcdh α and γ … fleetwood 10k results