Paclitaxel resistance

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August undefined, 2024

WebAug 23, 2024 · Platinum plus paclitaxel is a first-line chemotherapy for ovarian cancer. Platinum resistance is a hot topic for many scholars, but drug resistance caused by paclitaxel is also a topic of concern. Currently, scholars believe that inhibition of MAPK signaling pathway may be an effective way to reverse the drug resistance of tumor … WebApr 27, 2024 · Identification of ALDH2 as a paclitaxel resistance-related gene in NSCLC cells. We first measured the resistance index (RI) value of the NSCLC/PTX cells to confirm PTX resistance. Results showed that the PTX resistance index of NSCLC/PTX cells is greater than 15 (Fig. S1A). Thus, the cells are highly drug-resistant and can be used in …

Paclitaxel-Resistant Cell Line - an overview - ScienceDirect

WebOct 21, 2024 · PTX resistance mechanisms are different and involve alterations in α- and β-tubulin, increased expression and activity of multidrug resistance (MDR) efflux transporters, overexpression of anti-apoptotic proteins, inhibition of apoptotic and tumor-suppressor proteins, and modulation of several cytokines, chemokines, and transcription factor … WebA TPGS-incorporating nanoemulsion of paclitaxel circumvents drug resistance in breast cancer. Int J Pharm. 2014;471(1–2):206–213. 38. Chen F, Wu J, Zheng C, et al. TPGS modified reduced bovine serum albumin nanoparticles as a lipophilic anticancer drug carrier for overcoming multidrug resistance. tax id for englewood hospital

Characterization of acquired paclitaxel resistance of …

WebWe identified that once in the EGFR-TKI persister state, paclitaxel-resistant cells enrich their stemness profile and rewire their glucose metabolism and an apoptotic control … WebOct 22, 2010 · In vitro, the overexpression of the βIII subunit induces paclitaxel resistance, possibly by decreasing paclitaxel’s binding to βIII-tubulin and disrupting the microtubule dynamics . This phenotype was seen in a leukemia cell line that was resistant to vinblastine, which was also cross-resistant to other vinca alkaloids and paclitaxel [ 48 ]. WebWe used GEO data to generate paclitaxel resistance in two basal-like TNBC cell lines (SUM149 and MDA-MB-468). Seventy-one common upregulated differentially expressed … the christmas carol show

Autophagy promotes paclitaxel resistance of cervical cancer cells ...

Effect of circHIPK3 on PTX resistance of Breast Cancer. CMAR

WebFeb 27, 2006 · Resistance to paclitaxel in laboratory cell line models has been extensively explored, and various mechanisms of resistance have been identified ( 4 – 6 ). One reported mechanism is the overexpression of ABC transporters, including P-glycoprotein/MDR1/ABCB1, ABCB4 (MDR2), ABCB11 (BSEP and SPGP; ref. 7 – 9 ), and … WebJan 1, 2024 · Mechanisms of paclitaxel resistance by cancer cells have yet to be fully elucidated. One of the recent reviews broadly described the paclitaxel resistance mechanism in cancer cell caused by MDR efflux transporters overexpression, altered expression of microtubule-associated proteins or microtubule alternation (Das et al., … tax id for limited liability companyWebDec 16, 2024 · Paclitaxel has been used widely to treat breast cancer and other types of cancer. However, resistance is a major cause of failure for treatment and results in … the christmas changeup

"WebAug 4, 2024 · Circular RNAs (circRNAs) and epithelial to mesenchymal transition (EMT) have been implicated in the development of human cancer and paclitaxel resistance. CircRNA circ_0007534 has been described as a key oncogenic circular RNA that is upregulated in a variety of cancer tissues. However, whether circ_0007534 causes EMT … " - Paclitaxel resistance

Paclitaxel resistance

Quantitative proteomic analysis of ovarian cancer cells identified ...

WebPaclitaxel (PTX) is a first-line drug for late-stage non-small cell lung cancer (NSCLC) patients who do not benefit from targeted therapy or immunotherapy. However, patients invariably develop resistance to PTX upon prolonged treatments. Although diverse mechanisms leading to PTX resistance have bee … WebNov 1, 2016 · To address this issue, we established paclitaxel-resistant sublines of the SK-BR-3 and MCF-7 breast cancer cell lines that are capable of long-term proliferation in …

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WebFeb 24, 2024 · Paclitaxel resistance is a challenging factor in chemotherapy resulting in poor prognosis and cancer recurrence. Signal transducer and activator of transcription factor 3 (STAT3), a key …

WebAug 14, 2014 · Paclitaxel is one of the most effective chemotherapy drugs for advanced cervical cancer. However, acquired resistance of paclitaxel represents a major barrier to successful anticancer treatment. WebNov 24, 2024 · Cells with paclitaxel resistance were constructed by gradually increasing paclitaxel concentration. Among the four cell lines, MCF-7 and MDA-MB-231 grew relatively well under the action of paclitaxel; these drug-resistant cell lines were named MDA-MB-231-PR and MCF-7-PR.

WebMuch like paclitaxel resistance, a delay in G1 is likely to confer resistance by limiting entry into S phase in the presence of cisplatin, which will greatly reduce cisplatin’s ability to damage DNA. However, G1 delay-induced resistance to cisplatin may go beyond whether or not a cell enters S phase in the presence of the drug; our data ... WebAug 8, 2013 · To test whether paclitaxel -induced inflammatory responses protect cells from chemotherapy, we measured IC 50 of paclitaxel in TLR4 + MDA-MB-231 and TLR4-negative HCC1806 cells. As shown in Fig. 2A and B, TLR4 + MDA-MB-231 was 4-fold more resistant to paclitaxel as compared with HCC1806 (IC 50 of 12.5 vs.3.25 nmol/L; P = …

WebPaclitaxel has been widely used as an anti-mitotic agent in chemotherapy for a variety of cancers and adds substantial efficacy as the first-line chemotherapeutic regimen for …

WebWe used GEO data to generate paclitaxel resistance in two basal-like TNBC cell lines (SUM149 and MDA-MB-468). Seventy-one common upregulated differentially expressed genes (DEGs) and 11 downregulated DEGs were found to be related to paclitaxel resistance. By constructing protein-protein interactions, 28 hub proteins with a degree … tax id for freeWebA TPGS-incorporating nanoemulsion of paclitaxel circumvents drug resistance in breast cancer. Int J Pharm. 2014;471(1–2):206–213. 38. Chen F, Wu J, Zheng C, et al. TPGS … the christmas carrollsWebAug 4, 2024 · Conventional frontline treatment for ovarian cancer consists of successive chemotherapy cycles of paclitaxel and platinum. Despite the initial favorable responses … the christmas checklist filming locationWebDec 21, 2024 · Warning. This medicine may lower the ability of the bone marrow to make blood cells that the body needs. If blood cell counts get very low, this can lead to … tax id for medical providerWebWe conducted a phase II trial to evaluate the safety and efficacy of weekly paclitaxel in patients with resistant or relapsed non-small cell lung cancer (NSCLC) treated with docetaxel and carboplatin. Thirty-two NSCLC patients at a median age of 58.0 years (range 33-75) were enrolled. The Eastern Co … the christmas channel tvWebOct 9, 2024 · Abstract We investigated the molecular mechanisms of paclitaxel resistance in TNBC using seven patient-derived xenograft (PDX) models and TNBC cell lines. Among the seven PDX models, four models showed resistance to paclitaxel. Dysregulation of JAK/STAT pathways and JAK2 copy number gains were observed in the four paclitaxel … the christmas carol with alastair simWebJan 13, 2024 · Background: Drug resistance is a major obstacle in chemotherapy for ovarian cancer, wherein the up regulation of drug-resistant genes plays an important … the christmas castle in scotland book